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MYP_128117
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Basic Information
Thymosin beta-4
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological regulation
Standard
43 amino acids
C210H348N56O77S
Standard
Sequence
SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Physicochemical Analysis
4921.40 Da
5.02
-2.52
-2.76
-0.0587
-1.70
0.41
-0.41
61.69
40.93
0.0233
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2217.60
-25.58
72.0
76.0
179.0
344.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0202597 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; Homo sapiens [Animal]; Rattus norvegicus [Animal]; Mus musculus [Animal]; Sus scrofa [Animal]; Equus caballus [Animal]; Chinchilla lanigera [Animal]; Taeniopygia guttata,Poephila guttata [Animal]
9913, 9606, 10116, 10090, 9823, 9796
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Blocked
Bio-Activity Profile
Immunomodulatory
RECORD: Rec_0221334 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Thymosin
10116
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
1:Phosphoserine; 3:N6-acetyllysine; 11:N6-acetyllysine; 22:Phosphothreonine; 25:N6-acetyllysine; 30:Phosphoserine; 31:N6-acetyllysine; 33:Phosphothreonine; 38:N6-acetyllysine
Bio-Activity Profile
Cardiovascular Growth regulation Development regulation Immunomodulatory
-
Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Thymosin beta-4 (Rattus norvegicus): PMID 6201851 PMID6201851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6201851/
RECORD: Rec_0233022 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Thymosin
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
1:Phosphoserine; 3:N6-acetyllysine; 11:N6-acetyllysine; 22:Phosphothreonine; 25:N6-acetyllysine; 30:Phosphoserine; 31:N6-acetyllysine; 33:Phosphothreonine; 38:N6-acetyllysine
Bio-Activity Profile
Cardiovascular Immunomodulatory
-
Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Thymosin beta-4 (Homo sapiens): PMID 25946035 PMID25946035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25946035/
RECORD: Rec_0359988 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
thymosin beta family
9913; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
1-Ser: Phosphoserine; 3-Lys: N6-acetyllysine; 11-Lys: N6-acetyllysine; 22-Thr: Phosphothreonine; 25-Lys: N6-acetyllysine; 30-Ser: Phosphoserine; 31-Lys: N6-acetyllysine; 33-Thr: Phosphothreonine; 38-Lys: N6-acetyllysine
Bio-Activity Profile
Hormone thymosin beta family
PaperPDB 3SJH structural record; X-ray; 1.75 A; chain B; residues 17-43
RECORD: Rec_0375527 VERIFIED: NO
Provenance & Taxonomy
Bos taurus indicus [Animal]
9915
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
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