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MYP_128061
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Basic Information
Cycloviolacin-H4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Trypsin inhibitor
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C131H206N34O42S6
Standard
Sequence
CAESCVWIPCTVTALLGCSCSNNVCYNGIP
Physicochemical Analysis
3121.63 Da
4.05
-1.30
-1.59
-0.0432
0.79
0.23
0.32
31.07
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1193.38
-14.59
46.0
47.0
92.0
213.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0120209 VERIFIED: NO
Provenance & Taxonomy
Viola hederacea [Plant]
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
RECORD: Rec_0253865 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anti-HIV Antimicrobial Cytotoxic Neurotensin antagonistic Trypsin inhibitor Insecticide
Human erythrocytes
5.5 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/16441062/ PMID16441062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16441062/
RECORD: Rec_0304225 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID 16441062 PMID16441062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16441062/
RECORD: Rec_0330025 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 33.3%, E 0.0%, T 40.0%, C 26.7% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Toxic Antimicrobial Hemolytic Cytotoxic Trypsin inhibitor Insecticidal manual_review_only
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0413222 VERIFIED: NO
Provenance & Taxonomy
Viola hederacea [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-18; 5-20; 10-25
Bio-Activity Profile
Antimicrobial