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MYP_127961
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Basic Information
de novo designed peptide (penetratin analogue)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C150H235N45O27
Standard
Sequence
LIRLWSHLIHIWFQNRRLKWKKK
Physicochemical Analysis
3100.76 Da
12.00
6.93
6.62
0.3013
-0.63
0.62
-0.18
65.54
118.70
0.1739
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1204.44
-2.83
45.0
36.0
105.0
222.0
9.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105507 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Membrane-active peptide
PaperFerrer - Miralles N., Vazquez E., Villaverde A.. Membrane-active peptides fro non-viral gene therapy: making the safest easier. Trends Biotechnol., 2008, 26, 5, 267-275.
RECORD: Rec_0122083 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID17463227 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17463227/
RECORD: Rec_0207267 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Penetratin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
not reported
Amidation
Bio-Activity Profile
Cell-penetrating peptide
HepG2 cells
Cellular uptake assay
PMID17463227 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17463227/
RECORD: Rec_0212976 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID17463227 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17463227/
RECORD: Rec_0220441 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
EB1
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22281502 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22281502/
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