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MYP_127941
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Basic Information
Magainin-2 [G13,18a], Magainin H
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
23 amino acids
C116H184N30O29S
Standard
Sequence
GIGKFLHSAKKFAKAFVAEIMNS
Physicochemical Analysis
2494.95 Da
10.00
2.85
2.59
0.1237
0.27
0.69
0.19
10.56
80.87
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
957.13
-7.11
33.0
34.0
86.0
176.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063506 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
U-937
19 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
RECORD: Rec_0065592 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
50 μg/mL
MIC
PMID3410055 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0069997 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
NCI-H526
10.5 μM
IC50
PaperMagainin analogs effective against pathogenic protozoa PMID1319823;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319823/
RECORD: Rec_0074972 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
NCI-H182
12.5 μM
IC50
PaperMagainin analogs effective against pathogenic protozoa PMID1319823;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319823/
RECORD: Rec_0101340 VERIFIED: YES
Provenance & Taxonomy
Antheraea pernyi [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
8402
16 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
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