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MYP_127941
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Basic Information
Magainin-2 [G13,18a], Magainin H
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
23 amino acids
C116H184N30O29S
Standard
Sequence
GIGKFLHSAKKFAKAFVAEIMNS
Physicochemical Analysis
2494.95 Da
10.00
2.85
2.59
0.1237
0.27
0.69
0.19
10.56
80.87
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
957.13
-7.11
33.0
34.0
86.0
176.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
25 μg/mL
MIC
PMID3410055 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0007791 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae ATCC 13883
100 μg/mL
MIC50
PMID3410055 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0022867 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Magainin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus agalactiae ATCC 12386
100 μg/mL
MIC50
PMID3410055 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3410055/
RECORD: Rec_0036294 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
NCI-H735
7.23 μM
IC50
PaperMagainin analogs effective against pathogenic protozoa PMID1319823;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319823/
RECORD: Rec_0050150 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Magainin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Beta-alanine
Amidation
Bio-Activity Profile
Antibacterial
Raji
25 μg/mL
IC50
PaperAntibiotic magainins exert cytolytic activity against transformed cell lines through channel formation PMID1708887;2285300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1708887/
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