Peptide Database

Peptide NameFSEC

Function Ontology

Anticancer

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC48H77N13O21S3

DescriptionStandard

        CELDENNTPMC
    

Molecular Weight1268.39 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.25

Net Charge (pH 7.4) -3.49

Charge Density (pH 7.0) -0.2957

GRAVY Index-0.83

Hydrophobic Moment 0.13

Boman Index-0.14

Instability Index-5.48

Aliphatic Index 35.45

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 563.84

LogP -7.25

H-bond Donors 19.0

H-bond Acceptors 21.0

Rotatable Bonds 40.0

Heavy Atoms 85.0

Ring Count 1.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423727 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySPARC-derived peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-11

Bio-Activity Profile

Function

Antiangiogenic Antitumor Anticancer

TargetHUVEC; bFGF-stimulated endothelial-cell migration

Activity~1 pM

MethodEC50 (bFGF-stimulated HUVEC migration assay)

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