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MYP_127873
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
45 amino acids
C216H377N75O59S6
Standard
Sequence
GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
Physicochemical Analysis
5161.16 Da
10.08
10.70
10.39
0.2377
-0.70
0.63
-0.36
53.13
67.11
0.0444
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2249.60
-26.02
89.0
76.0
182.0
356.0
3.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0116798 VERIFIED: NO
Provenance & Taxonomy
Pongo pygmaeus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1872
RECORD: Rec_0123679 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus aureus ATCC 43300
80 μM
Total countable CFUs
PaperHuman β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation PMID23273885 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23273885/
RECORD: Rec_0131816 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer Pubmed ID 11085990: Staphylococcus aureus
2.5 μg/mL
MIC
PMID11085990;35052952 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11085990/
RECORD: Rec_0137833 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli MG1655
2 μM
MBC
PMID28423004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423004/
RECORD: Rec_0140264 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
No Hemolytic activity
Hemolysis
PMID11085990;35052952 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11085990/
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