Peptide Database

Peptide NameSLAY-screened peptide P1536

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H164N34O30

DescriptionStandard

        RPDYALYHKPSDRANWVHYW
    

Molecular Weight2574.81 Da

Isoelectric Point (pI)8.44

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.62

Charge Density (pH 7.0) 0.0466

GRAVY Index-1.40

Hydrophobic Moment 0.33

Boman Index-0.20

Instability Index54.66

Aliphatic Index 44.00

Aromaticity 0.2500

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1036.01

LogP -5.94

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 73.0

Heavy Atoms 185.0

Ring Count 11.0

Amide Bonds 20.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0377180 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/