‹ ›
MYP_127835
← PREVIOUS NEXT → BACK
Basic Information
5-Fluoro-4-(N-succinamoyl-L-alanyl-L-leucine benzyl ester)-2(1H)-pyrimidone (compound 9)
Antimicrobial
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
2 amino acids
C9H18N2O3
Standard
Sequence
AL
Physicochemical Analysis
202.25 Da
5.57
-0.20
-0.39
-0.1021
2.80
0.57
0.84
5.00
245.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
92.42
-0.05
3.0
3.0
5.0
14.0
0.0
1.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0113501 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-Fluoro-4-N-succinamoyl
Benzyl ester-2(1H)-pyrimidone
Conjugation of peptide C terminal carboxyl group with amino group of 5 Fluorocytosine
Bio-Activity Profile
Antifungal Antimicrobial
20 μg/mL
MIC
Sample cells, in vivo; 3960 s
PMID385880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/385880/
RECORD: Rec_0177114 VERIFIED: YES
Provenance & Taxonomy
Citellus undulatus [Animal] [Animal]; Lysteria monocytogenes [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory DPP-IV Inhibitory
Dipeptidyl peptidase IV
882.13 ± 68.66 μM
IC50
RECORD: Rec_0190593 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Lactoferrin-derived
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
882.13 μM
IC50
PaperDipeptidyl peptidase IV inhibitory and antioxidative properties of milk protein-derived dipeptides and hydrolysates | Nongonierma, A. et al. | DOI: 10.1016/j.peptides.2012.11.016 Evidence URLhttps://www.uniprot.org/uniprotkb/P02788/entry
RECORD: Rec_0301215 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-Fluoro-4-N-succinamoyl
2-(1H)-pyrimidone
Conjugation of peptide C terminal carboxyl group with amino group of 5 Fluorocytosine
Bio-Activity Profile
Antifungal Antimicrobial
10 μg/mL
MIC
Sample cells, in vivo; 6120 s
PMID385880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/385880/
RECORD: Rec_0302948 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2