Peptide Database

Peptide NameSLAY-screened peptide P3003

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC65H89N15O19

DescriptionStandard

        HHYTTYLSYSI
    

Molecular Weight1384.49 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.38

Charge Density (pH 7.0) -0.0062

GRAVY Index-0.45

Hydrophobic Moment 0.23

Boman Index0.18

Instability Index41.32

Aliphatic Index 70.91

Aromaticity 0.2727

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 553.29

LogP -4.14

H-bond Donors 21.0

H-bond Acceptors 21.0

Rotatable Bonds 39.0

Heavy Atoms 99.0

Ring Count 5.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0392237 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/