Peptide Database

Peptide NameSLAY-screened peptide P756

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC123H179N31O31

DescriptionStandard

        NRLDLRSIYKPHNFDIYFIY
    

Molecular Weight2587.93 Da

Isoelectric Point (pI)8.44

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0423

GRAVY Index-0.48

Hydrophobic Moment 0.50

Boman Index-0.05

Instability Index47.83

Aliphatic Index 97.50

Aromaticity 0.2500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1027.63

LogP -5.01

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 81.0

Heavy Atoms 185.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359075 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/