Peptide Database

Peptide NameDefensin-NV

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length52 amino acids

Chemical FormulaC228H365N65O71S8

DescriptionStandard

        VTCELLMFGGVVGDSACAANCLSMGKAGGSCNGGLCDCRKTTFKELWDKRFG
    

Molecular Weight5409.25 Da

Isoelectric Point (pI)7.74

Net Charge (pH 7.0)0.68

Net Charge (pH 7.4) 0.37

Charge Density (pH 7.0) 0.0131

GRAVY Index0.15

Hydrophobic Moment 0.31

Boman Index0.10

Instability Index43.09

Aliphatic Index 61.92

Aromaticity 0.0769

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2185.15

LogP -26.31

H-bond Donors 83.0

H-bond Acceptors 80.0

Rotatable Bonds 182.0

Heavy Atoms 372.0

Ring Count 5.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0210791 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitystereochemistry not specified [Other]

N-TermNone

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

RECORD: Rec_0283352 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitystereochemistry not specified [Other]

N-TermNone

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans

Activity1.86 μM

MethodMIC

RECORD: Rec_0289613 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitystereochemistry not specified [Other]

N-TermNone

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetBacillus cereus

Activity0.93 μM

MethodMIC

RECORD: Rec_0303248 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyDefensin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

RECORD: Rec_0381223 VERIFIED: YES

Provenance & Taxonomy

OrganismNasonia vitripennis [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitystereochemistry not specified [Other]

N-TermNone

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targetrabbit red blood cells

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