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MYP_127603
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Basic Information
Epinecidin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
21 amino acids
C114H175N29O22S
Standard
Sequence
GFIFHIIKGLFHAGKMIHGLV
Physicochemical Analysis
2335.85 Da
10.00
2.02
1.66
0.0962
1.09
0.59
0.54
34.78
130.00
0.1429
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
783.40
-0.79
27.0
28.0
77.0
166.0
6.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0187502 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
[ Refer Pubmed ID 35052952: Carbapenem-resistant Klebsiella pneumoniae Bacterial isolates CRKP-1 (
32 μg/mL
MIC
PMID30552913;28882626;17570764;35052952 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30552913/
RECORD: Rec_0200719 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus agalactiae(MIC>=100 mg/L)
PMID23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598079/
RECORD: Rec_0216341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Micrococcus luteus
6.25 μg/mL
MIC
PMID23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598079/
RECORD: Rec_0217307 VERIFIED: YES
Provenance & Taxonomy
Musca domestica [Animal]
Epinecidin
7370
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
50 μg/mL
Cytotoxicity assay
PaperTruncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus PMID23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598079/
RECORD: Rec_0240813 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Antiparasitic Anti-inflammatory Wound healing
BHK-21 cells
19.5 μg/mL
TC50
PaperGene expression and localization of the epinecidin-1 antimicrobial peptide in the grouper (Epinephelus coioides), and its role in protecting fish against pathogenic infection. PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
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