Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length141 amino acids

Chemical FormulaC703H1075N185O189S7

DescriptionStandard

        MPVTARLDPFAAFDYSLVSKPMIARDHGDMDLKGEFYGVGKHTESPFSPAPFLLPDEGDRMLLLGLSEFSANSAAFVYFTAGALRKKLTDSMIPKRSPIRLNTRSLGLFCPQVSQPGAGHCWIWAKPPPGLAPGPRPWAPP
    

Molecular Weight15366.64 Da

Isoelectric Point (pI)9.03

Net Charge (pH 7.0)2.75

Net Charge (pH 7.4) 2.33

Charge Density (pH 7.0) 0.0195

GRAVY Index-0.16

Hydrophobic Moment 0.62

Boman Index0.10

Instability Index51.21

Aliphatic Index 72.77

Aromaticity 0.1064

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5785.39

LogP -49.01

H-bond Donors 197.0

H-bond Acceptors 202.0

Rotatable Bonds 472.0

Heavy Atoms 1084.0

Ring Count 40.0

Amide Bonds 144.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366135 VERIFIED: NO

Provenance & Taxonomy

OrganismPelodiscus sinensis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence