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MYP_127531
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Basic Information
AA139
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C108H165N39O26S4
Standard
Sequence
GFCWYVCARRNGARVCYRRCN
Physicochemical Analysis
2553.97 Da
9.69
4.72
4.45
0.2247
-0.43
0.57
-0.29
61.98
37.14
0.1905
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1097.25
-11.64
46.0
35.0
79.0
177.0
5.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099154 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Arenicin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae
8.0 μg/mL
MIC
PaperAntimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles.
RECORD: Rec_0111557 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human embryonic kidney HEK293 cells (50% Cell death at >300 microg/ml, Human kidney proximal tubule HK-2 cells (50% Cell death at >250 microg/ml
293 μg/mL
Hemolysis
PMID32576824;35523364 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32576824/
RECORD: Rec_0188551 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae BAA-2146
1 μg/mL
MIC
PMID32576824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32576824/
RECORD: Rec_0198876 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Arenicin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa
2-16.0 μg/mL
MIC
PaperAntimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles.
RECORD: Rec_0269567 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Arenicin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
8.0 μg/mL
MIC
PaperAntimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles.
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