Peptide Database

Peptide NameSLAY-screened peptide P3188

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC60H88N18O17S

DescriptionStandard

        VYCQNPRHVYS
    

Molecular Weight1365.52 Da

Isoelectric Point (pI)8.18

Net Charge (pH 7.0)0.81

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0736

GRAVY Index-0.80

Hydrophobic Moment 0.37

Boman Index-0.15

Instability Index-3.44

Aliphatic Index 52.73

Aromaticity 0.1818

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 582.98

LogP -5.75

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 39.0

Heavy Atoms 96.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033181 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/