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MYP_127510
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Basic Information
Defensin D2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C233H359N69O70S8
Standard
Sequence
KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC
Physicochemical Analysis
5503.28 Da
8.48
2.86
2.42
0.0571
-0.49
0.36
-0.07
28.13
43.00
0.1000
9970.00
10470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2239.00
-26.36
86.0
83.0
179.0
380.0
10.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249876 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Fusarium culmorum (IC50=6.9 μg/ml) and Botrytis cinerea
13.7 μg/mL
IC50
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0254284 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Clavibacter michiganensis (1.5 cm) and Bacillus subtilis (1.3 cm)
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0277150 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Fusarium culmorum
6.9 μg/mL
IC50
PaperPubMed PMID 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0279781 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Fusarium oxysporum
5.3 μg/mL
IC50
PaperPubMed PMID 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0290508 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Antifungal Non-hemolytic
Fusarium oxysporum
PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
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