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MYP_127510
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Basic Information
Defensin D2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
50 amino acids
C233H359N69O70S8
Standard
Sequence
KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKLPAHRCICYYEC
Physicochemical Analysis
5503.28 Da
8.48
2.86
2.42
0.0571
-0.49
0.36
-0.07
28.13
43.00
0.1000
9970.00
10470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2239.00
-26.36
86.0
83.0
179.0
380.0
10.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0164811 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Antifungal Non-hemolytic
Bipolaris sorokiniana
PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0186979 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Erwinia carotovora (0.7 cm) and Escherichia coli (1.4 cm)
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0187819 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Aspergillus niger
3.5 μg/mL
IC50
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0190044 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
NOTE: Inhibition zone
PaperPubMed PMID: 21144761 PMID21144761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144761/
RECORD: Rec_0230137 VERIFIED: YES
Provenance & Taxonomy
Nigella sativa [Plant]
Defensin
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
3-50, 14-35, 20-44, 24-46
Bio-Activity Profile
Antimicrobial Antifungal
Aspergillus niger
3.5 μg/mL
IC50
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