Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length396 amino acids

Chemical FormulaC2023H3130N500O587S16

DescriptionStandard

        MAQVQVQVLWGCFILWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFLKIDYVNYNFTNIKINAFSFPNTSLAFVPGVGIRALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFVEPMEKPILKKLNEMLCPIITGEVEALNANLSKLEVLRKIDNYTLLDYSLVSSPEITENYFDLNLKGVFYPLKSLQYPPFPSVPFVLPERSDSMLYIGISKYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQALGNMLSRIAELYILSQPFMVQVMATEPPVVRNFTLDIPASIMILTQPKNSTAETIVSMDFDEKEGFNKNRTSGCGKQ
    

Molecular Weight44360.53 Da

Isoelectric Point (pI)5.51

Net Charge (pH 7.0)-6.06

Net Charge (pH 7.4) -6.70

Charge Density (pH 7.0) -0.0153

GRAVY Index0.03

Hydrophobic Moment 0.68

Boman Index0.14

Instability Index33.97

Aliphatic Index 93.81

Aromaticity 0.1162

Extinction Coeff. Reduced 43320.00

Extinction Coeff. Oxidized 43570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0327340 VERIFIED: NO

Provenance & Taxonomy

OrganismCervus elaphus hippelaphus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence