Peptide Database

Peptide NameTeixobactin derivative 5

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC64H115N15O14

DescriptionStandard

        FIKKIISTKKI
    

Molecular Weight1318.69 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.3415

GRAVY Index0.34

Hydrophobic Moment 0.35

Boman Index0.04

Instability Index-14.06

Aliphatic Index 141.82

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 498.86

LogP -1.44

H-bond Donors 18.0

H-bond Acceptors 18.0

Rotatable Bonds 49.0

Heavy Atoms 93.0

Ring Count 1.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0324738 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermMethylation

Other ModsN-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.

Bio-Activity Profile

Function

Hemolytic

TargetRBC

Activity>64 μg/mL

MethodHemolysis

RECORD: Rec_0345852 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermMethylation

Other ModsN-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

Activity4 μg/mL

MethodMIC

RECORD: Rec_0400170 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermMethylation

Other ModsN-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

Activity8 μg/mL

MethodMIC

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