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MYP_127396
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Basic Information
Teixobactin derivative 5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
11 amino acids
C64H115N15O14
Standard
Sequence
FIKKIISTKKI
Physicochemical Analysis
1318.69 Da
10.48
3.76
3.55
0.3415
0.34
0.35
0.04
-14.06
141.82
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
498.86
-1.44
18.0
18.0
49.0
93.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0133785 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6051
0.5 μg/mL
MIC
PMID30050518;28795808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0145056 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 29213
2 μg/mL
MIC
PMID30050518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0175746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
2 μg/mL
MIC
PMID30050518;28795808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0177586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
32 μg/mL
MIC
PMID30050518;28795808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0291513 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
64 μg/mL
MIC
PMID30050518;28795808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
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