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MYP_127305
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Basic Information
Phakellistatin 4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
7 amino acids
C41H57N7O10
Standard
Sequence
PTPFIFS
Physicochemical Analysis
807.93 Da
5.96
-0.04
-0.10
-0.0059
0.77
0.16
0.54
36.09
55.71
0.2857
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
255.60
-0.86
9.0
10.0
20.0
58.0
4.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261377 VERIFIED: YES
Provenance & Taxonomy
Phakellia costata [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
t=D-Thr; f=D-Phe; i=D-Ile
Bio-Activity Profile
Antimicrobial Anticancer
A549
7.4 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0275404 VERIFIED: YES
Provenance & Taxonomy
Phakellia costata [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
t=D-Thr; f=D-Phe; i=D-Ile
Bio-Activity Profile
Antimicrobial Anticancer
K562
30 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0354368 VERIFIED: YES
Provenance & Taxonomy
Phakellia costata [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
t=D-Thr; f=D-Phe; i=D-Ile
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0372833 VERIFIED: YES
Provenance & Taxonomy
Phakellia costata [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
t=D-Thr; f=D-Phe; i=D-Ile
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: MDA-MB-231
10 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
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