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MYP_127234
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Basic Information
ChaC11
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C129H199N31O38S7
Standard
Sequence
IPCGESCVWIPCISGMFGCSCKDKVCYS
Physicochemical Analysis
3016.60 Da
6.03
-0.30
-0.60
-0.0107
0.61
0.28
0.26
20.91
62.50
0.1071
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.02
-10.34
43.0
45.0
93.0
205.0
6.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0325086 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic
Human cervical carcinoma HeLa
1.2 μM
IC50
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0371405 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0376516 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic Anti-Gram-positive
Staphylococcus epidermidis
80 μM
MIC
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0387156 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 35.7%, E 0.0%, T 46.4%, C 17.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0392712 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
M at position 16 is oxidated
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Cytotoxic Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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