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MYP_127234
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Basic Information
ChaC11
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C129H199N31O38S7
Standard
Sequence
IPCGESCVWIPCISGMFGCSCKDKVCYS
Physicochemical Analysis
3016.60 Da
6.03
-0.30
-0.60
-0.0107
0.61
0.28
0.26
20.91
62.50
0.1071
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.02
-10.34
43.0
45.0
93.0
205.0
6.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0112220 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic Anti-Gram-positive
Staphylococcus aureus
80 μM
MIC
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0119724 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0135678 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0148588 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
80 μM
MIC
PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0192018 VERIFIED: YES
Provenance & Taxonomy
Curved flower [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
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