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MYP_127230
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Basic Information
L-K6
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C75H145N19O15
Standard
Sequence
IKKILSKIKKLLK
Physicochemical Analysis
1553.07 Da
10.70
5.75
5.54
0.4426
0.05
0.80
-0.14
-15.14
180.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
588.87
-0.74
21.0
21.0
62.0
109.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0343096 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
7.8 μg/mL
MIC
PMID26473368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26473368/
RECORD: Rec_0346110 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
7.8 μg/mL
MIC
PMID26473368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26473368/
RECORD: Rec_0353920 VERIFIED: YES
Provenance & Taxonomy
some cationic antimicrobial peptides [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
34 μM
IC50
PaperPubMed PMID: 28811617 PMID28811617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28811617/
RECORD: Rec_0371785 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
100 μg/mL
MIC
PMID26473368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26473368/
RECORD: Rec_0377080 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Enterococcus faecalis
3.13 μM
MIC
PaperInvestigation of the role of tryptophan residues in cationic antimicrobial peptides to determine the mechanism of antimicrobial action.
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