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MYP_127161
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Basic Information
Circulin B
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C145H231N37O40S6
Standard
Sequence
GTFPCGESCVWIPCISKVIGCACKSKVCYKN
Physicochemical Analysis
3325.00 Da
8.65
2.70
2.40
0.0870
0.43
0.55
0.18
31.90
69.03
0.0968
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1220.15
-11.92
48.0
49.0
105.0
228.0
6.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022212 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0032348 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0215780 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperThe alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity.
RECORD: Rec_0240995 VERIFIED: NO
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0285826 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Cytotoxic
PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
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