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MYP_127077
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Basic Information
peptide 22 (Derived from B1)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
7 amino acids
C39H68N10O9
Standard
Sequence
KKKLAYA
Physicochemical Analysis
821.02 Da
10.00
2.76
2.55
0.3937
-0.80
0.28
-0.28
30.27
84.29
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
336.21
-1.27
12.0
12.0
29.0
58.0
1.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177330 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0224794 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Gram-positive bacteria: MRSP C22963
16 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0229310 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
32 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0241635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Residue 5 and residue 7 are 1-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: MRSP C22963
2-4 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
RECORD: Rec_0284795 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Residue 5 and residue 7 are 2-naphthylmethylglycine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Pseudomonas aeruginosa
64 μg/mL
MIC
PaperCharacterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections PMID30842436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30842436/
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