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MYP_127030
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C69H127N17O12
Standard
Sequence
KKLFKKILKKL
Physicochemical Analysis
1386.85 Da
10.70
5.75
5.54
0.5231
-0.43
0.81
-0.30
-17.94
141.82
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
510.44
0.45
18.0
18.0
55.0
98.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020290 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: sulfonamide; Conjugated small molecule: Tosyl chloride
Bio-Activity Profile
Antimicrobial Anticancer
PaperCell-penetrating ¦Ã-peptide/antimicrobial undecapeptide conjugates with anticancer activity Evidence URLhttps://doi.org/10.1016/j.tet.2012.02.003
RECORD: Rec_0046254 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: (2S,2S¡ä)-1,1¡ä-bis(pyrid-2-ylmethyl)-2,2¡ä-bipyrrolidine ((S,S¡ä)-BPBP)
Bio-Activity Profile
Anticancer
HeLa, Cancer cells
PaperDelivering aminopyridine ligands into cancer cells through conjugation to the cell-penetrating peptide BP16. Organic & Biomolecular Chemistry. 2016 Evidence URLhttps://doi.org/10.1039/c6ob00470a
RECORD: Rec_0075001 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
F. oxysporum
0.6-1.2 μM
MIC
PMID19617390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19617390/
RECORD: Rec_0078258 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Tosylation
Amidation
Bio-Activity Profile
Hemolytic
Human RBC
50 μM
Hemolysis
PMID17980935 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17980935/
RECORD: Rec_0079988 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Benzoylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas syringae
2.5
MIC
PMID17980935 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17980935/
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