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MYP_126966
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Basic Information
Hainanenin 5
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C107H181N29O25S2
Standard
Sequence
FALGAVTKRLPSLFCLITRKC
Physicochemical Analysis
2337.89 Da
10.11
3.74
3.50
0.1780
0.81
0.57
0.15
44.48
116.19
0.0952
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
873.06
-5.96
34.0
31.0
76.0
163.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014500 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
E. faecium 1299
4.7 μg/mL
MIC
PaperHainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis
RECORD: Rec_0018168 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 2592
18.8 μg/mL
MIC
PMID22306820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22306820/
RECORD: Rec_0018512 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0046838 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
C. glabrata 0902
37.5 μg/mL
MIC
PaperHainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis
RECORD: Rec_0047120 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 2592
18.8 μg/mL
MIC
PaperHainanenins: A novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis
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