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MYP_126952
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Basic Information
Mitoparan, Mastoparan [A5,8K;A10Aib]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
INLKKLAKLXKKIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0351721 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
X=AIB (Aminoisobutyric acid)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: U-373MG
13.95 μM
LD50
PMID22148546 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0408532 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 10
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Cryptococcus neoformans
0.67
MIC
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0418870 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 10
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Rat leukemia cells RBL-2H3
7.53 μM
EC50
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0426430 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
TAM
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Rhodamine conjugation
Aib, α-amino isobutyric acid
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22148546 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
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