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MYP_126952
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Basic Information
Mitoparan, Mastoparan [A5,8K;A10Aib]
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
INLKKLAKLXKKIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0175583 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Aib (α-aminoisobutyric acid) at position 10
Bio-Activity Profile
Hemolytic
HEK293 cells
50; 85.4-86.5 %
Cytotoxicity at 19.1-20.6 and 32 μg/mL
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0223104 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Aib (α-aminoisobutyric acid) at position 10
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
6.67 μM
MIC
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0241121 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Aib (α-aminoisobutyric acid) at position 10
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli
4.0 μM
MIC
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0243970 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Mastoparan
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Aib (α-aminoisobutyric acid) at position 10
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
U373-MG astrocytoma cells
20-30 %
Cell killing at 30 μM
PMID22148546;29337270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
RECORD: Rec_0271545 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
X=AIB (Aminoisobutyric acid)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID22148546 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22148546/
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