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MYP_126927
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Basic Information
Cycloviolin C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C133H217N37O40S6
Standard
Sequence
GIPCGESCVFIPCLTTVAGCSCKNKVCYRN
Physicochemical Analysis
3166.76 Da
8.33
1.70
1.40
0.0567
0.45
0.28
0.14
32.98
71.33
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1228.21
-14.86
48.0
48.0
99.0
216.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0289927 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 13.3%, E 0.0%, T 26.7%, C 60.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0307205 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0330664 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.13 μM
EC50
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0407024 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV
HIV-1
0.13 μM
EC50
PaperPubMed PMID 10813905 PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0417717 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
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