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MYP_126927
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Basic Information
Cycloviolin C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C133H217N37O40S6
Standard
Sequence
GIPCGESCVFIPCLTTVAGCSCKNKVCYRN
Physicochemical Analysis
3166.76 Da
8.33
1.70
1.40
0.0567
0.45
0.28
0.14
32.98
71.33
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1228.21
-14.86
48.0
48.0
99.0
216.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142329 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0186817 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Toxicity
0.56 μM
TC50
PaperCycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa.
RECORD: Rec_0208168 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0220724 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Defensin
341676
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.13 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0239514 VERIFIED: NO
Provenance & Taxonomy
Leonia cymosa [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
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