Peptide Database

Peptide NameAmphiregulin

Function Ontology

Immunology ▸ Immune modulation ▸ Cytokine modulation

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC428H702N138O132S7

DescriptionStandard

        SVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMK
    

Molecular Weight10117.45 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)10.59

Net Charge (pH 7.4) 10.15

Charge Density (pH 7.0) 0.1217

GRAVY Index-1.54

Hydrophobic Moment 0.55

Boman Index-0.45

Instability Index36.04

Aliphatic Index 32.41

Aromaticity 0.0575

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4528.38

LogP -55.54

H-bond Donors 159.0

H-bond Acceptors 152.0

Rotatable Bonds 361.0

Heavy Atoms 705.0

Ring Count 11.0

Amide Bonds 99.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0421356 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Familyamphiregulin family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide46-59; 54-70; 72-81

Bio-Activity Profile

Function

Cytokine Growth factor amphiregulin family Growth factor signaling