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MYP_126876
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Basic Information
HKU4-HR2P3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C201H308N46O64S2
Standard
Sequence
LDLSDEMAMLLQEVVKQLNDSYIDLKELGNYTYYNKW
Physicochemical Analysis
4457.00 Da
4.14
-4.23
-4.45
-0.1144
-0.47
0.65
0.01
40.75
102.70
0.1351
11460.00
11460.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1822.93
-12.39
61.0
62.0
151.0
313.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119246 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | 293T cells; Huh-7 cells
0.55 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPotent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4. | Xia S, Lan Q, Pu J, Wang C, Liu Z, Xu W, Wang Q, Liu H, Jiang S, Lu L. | Viruses. 2019 Jan 14;11(1):56. doi: 10.3390/v11010056 | DOI:10.3390/v11010056 | PMID:30646495 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0247409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
toxicity against Huh-7 cells up to 100 μM
100 μM
Cytotoxicity
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0361187 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV Q1020H | Huh-7 cells
0.52 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPotent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4. | Xia S, Lan Q, Pu J, Wang C, Liu Z, Xu W, Wang Q, Liu H, Jiang S, Lu L. | Viruses. 2019 Jan 14;11(1):56. doi: 10.3390/v11010056 | DOI:10.3390/v11010056 | PMID:30646495 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0419737 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV Q1020:inhibition of Pseudovirus Infection in Huh-7 cells
0.48 μM
IC50
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
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