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MYP_126876
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Basic Information
HKU4-HR2P3
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
37 amino acids
C201H308N46O64S2
Standard
Sequence
LDLSDEMAMLLQEVVKQLNDSYIDLKELGNYTYYNKW
Physicochemical Analysis
4457.00 Da
4.14
-4.23
-4.45
-0.1144
-0.47
0.65
0.01
40.75
102.70
0.1351
11460.00
11460.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1822.93
-12.39
61.0
62.0
151.0
313.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024207 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibitor Entry inhibitor
MERS-CoV Q1020H; Huh-7 cells
0.52±0.10 μM
IC50 (MERS-CoV Q1020H pseudovirus infection inhibition)
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0032690 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibitor Entry inhibitor
MERS-CoV; 293T/Huh-7 cell-cell fusion system; Huh-7 cells
Cell-cell fusion and pseudovirus infection inhibition assays
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0048111 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibitor Entry inhibitor
MERS-CoV; 293T/Huh-7 cell-cell fusion system
0.55±0.06 μM
IC50 (MERS-CoV S-mediated cell-cell fusion inhibition)
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0066564 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibitor Entry inhibitor
MERS-CoV Q1020; Huh-7 cells
0.48±0.08 μM
IC50 (MERS-CoV pseudovirus infection inhibition)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPotent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4. | Xia S, Lan Q, Pu J, Wang C, Liu Z, Xu W, Wang Q, Liu H, Jiang S, Lu L. | Viruses. 2019 Jan 14;11(1):56. doi: 10.3390/v11010056 | DOI:10.3390/v11010056 | PMID:30646495 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0094337 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibitor Entry inhibitor Non-cytotoxic
Huh-7 cells
>100 μM
Cytotoxicity assay (no cytotoxicity detected)
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/