Peptide Database

Peptide NameSLAY-screened peptide P2645

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H151N35O31

DescriptionStandard

        DPGWNYHFYSHRLQFHTNHS
    

Molecular Weight2543.67 Da

Isoelectric Point (pI)7.10

Net Charge (pH 7.0)0.11

Net Charge (pH 7.4) -0.30

Charge Density (pH 7.0) 0.0054

GRAVY Index-1.49

Hydrophobic Moment 0.21

Boman Index-0.12

Instability Index40.37

Aliphatic Index 19.50

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1067.56

LogP -10.12

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 74.0

Heavy Atoms 183.0

Ring Count 11.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0132165 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/