Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length457 amino acids

Chemical FormulaC2250H3647N581O634S15

DescriptionStandard

        MFPCCWLALVALIPVTLSTNPGVKVKLTAKGLEYGRQLGMASIQKKLKTIKVPDMSGTQKVPTIGKVRYSLTNLKIVDVGLPKSTLDLVPGTGVRLSIDNAFISLHGNWRVKYLRIIKDSGSFDLKVSGLTITTSIAIKSDETGRPVVSSVNCVTAVGSVSIKFHGGASWLYNLFKKFIDKALRKALEKQICNLVADVVSDLNLQLKTLNVVAKVDQYADIEYSMVSAPTVSKASIELGMKGEFYNTGKHREPPFSPAAFSLPPETNNMLYIGLSAFTANSAAFVYNTAGALSLYITDDMIPQGSPIRLNTRTFGTFIPQIAKRFPGLMMKLLVRTAKNPVVTFEPNNATVDATCTVTAYAIHPNATLSPLFVLNLETSVSARVFVSGTRLAGAVSLNKALDSIFQLVLKVVVIPILNVQLAKGYPLPTLGKMKLVNTQLQVLKDYVLIGTDVQFTG
    

Molecular Weight49462.51 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)20.80

Net Charge (pH 7.4) 20.21

Charge Density (pH 7.0) 0.0455

GRAVY Index0.25

Hydrophobic Moment 0.84

Boman Index0.16

Instability Index21.35

Aliphatic Index 107.46

Aromaticity 0.0766

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063500 VERIFIED: NO

Provenance & Taxonomy

OrganismCyclopterus lumpus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria