Peptide Database

Peptide NameCircularin A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC348H589N85O99S

DescriptionStandard

        MSLLALVAGTLGVSQSIATTVVSIVLTGSTLISIILGITAILSGGVDAILEIGWSAFVATVKKIVAERGKAAAIAW
    

Molecular Weight7579.97 Da

Isoelectric Point (pI)8.25

Net Charge (pH 7.0)0.50

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0066

GRAVY Index1.33

Hydrophobic Moment 0.46

Boman Index0.49

Instability Index26.06

Aliphatic Index 152.76

Aromaticity 0.0395

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2875.80

LogP -23.96

H-bond Donors 104.0

H-bond Acceptors 101.0

Rotatable Bonds 251.0

Heavy Atoms 533.0

Ring Count 5.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025089 VERIFIED: YES

Provenance & Taxonomy

OrganismGeobacillus kaustophilus [Bacterium]

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0195323 VERIFIED: NO

Provenance & Taxonomy

OrganismGeobacillus kaustophilus [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0216149 VERIFIED: NO

Provenance & Taxonomy

OrganismBacillus caldolyticus [Bacterium]

FamilyCircular bacteriocin

Structure & Mods

Configcyclic peptide topology reported [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Non-hemolytic Non-ribosomal

RECORD: Rec_0329029 VERIFIED: NO

Provenance & Taxonomy

OrganismGeobacillus stearothermophilus [Bacterium]

Structure & Mods

Configcyclic peptide topology reported [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Non-hemolytic Non-ribosomal

RECORD: Rec_0386136 VERIFIED: NO

Provenance & Taxonomy

OrganismGeobacillus kaustophilus [Bacterium]

Tax ID1462

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsCyclized peptide scaffold annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Non-hemolytic Non-ribosomal