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MYP_126711
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Basic Information
Apicidin
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Toxoplasma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
not Standard
4 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XIXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0231870 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic tetrapeptide
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Pipecolinyl, 2-amino-8-oxodecanoyl, N-O-methyl
Bio-Activity Profile
Antimicrobial Antiprotozoal Antiparasitic Anti-Toxoplasma
Toxoplasma gondii
0.008 μg/mL
MIC; [3H] Uracil incorporation assay
PaperApicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase PMID8917558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8917558/
RECORD: Rec_0290554 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
unknown
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: 34h; Xpr; Ag2
Bio-Activity Profile
-
RECORD: Rec_0330077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic tetrapeptide
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Pipecolinyl, 2-amino-8-oxodecanoyl, N-O-methyl
Bio-Activity Profile
Antimicrobial Antiprotozoal Antiparasitic Anti-Cryptosporidium
Cryptosporidium parvum
0.03 μg/mL
MIC; ELISA based assay
PaperApicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase PMID8917558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8917558/
RECORD: Rec_0334792 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic tetrapeptide
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Pipecolinyl, 2-amino-8-oxodecanoyl, N-O-methyl
Bio-Activity Profile
Antimicrobial Antiprotozoal Antiparasitic Anticoccidial
Eimeria tenella
0.062 μg/mL
MIC; [3H] Uracil incorporation assay
PaperApicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase PMID8917558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8917558/
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