Peptide Database

Peptide NameC-4 (analog of P18)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC103H165N25O17

DescriptionStandard

        KWKLFKKIPKFLHLAK
    

Molecular Weight2025.57 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.84

Net Charge (pH 7.4) 5.58

Charge Density (pH 7.0) 0.3651

GRAVY Index-0.36

Hydrophobic Moment 0.82

Boman Index-0.06

Instability Index-12.43

Aliphatic Index 103.75

Aromaticity 0.1875

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 691.62

LogP 1.33

H-bond Donors 24.0

H-bond Acceptors 24.0

Rotatable Bonds 70.0

Heavy Atoms 145.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418388 VERIFIED: YES

Provenance & Taxonomy

OrganismHyalophora cecropia [Animal]

FamilyCecropin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Cytotoxic

TargetK-562

Activity25 μM

MethodIC50

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