Peptide Database

Peptide NameRSV Fgp (497-515)[L7A;N4,A8,R11,E15 - S-ALA-4-pen]

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard Statusnot Standard

Sequence Length20 amino acids

Chemical Formula-

Descriptioncontains X representing unresolved or non-standard residue

        EKIXQSAXFIXKSDXLLHNV
    

Molecular Weight0.00 Da

Isoelectric Point (pI)0.00

Net Charge (pH 7.0)0.00

GRAVY Index0.00

Boman Index0.00

Instability Index0.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205246 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

Other ModsThe 'X' at positions 4, 8, 11 and 15 denotes S-pentenylalanine; X4-X8 and X11-X15 are hydrocarbon-stapled

Bio-Activity Profile

Function

Antiviral Anti-RSV Viral entry inhibitor Fusion inhibitor

TargetRespiratory syncytial virus (RSV); HEp-2 cells

Activity0.95±0.53 μM

MethodEC50 (rHRSV-mCherry infection inhibition assay)