Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length245 amino acids

Chemical FormulaC1257H1951N299O367S11

DescriptionStandard

        AKQFDDLVKVDYSLSGLPAVFQPFIDLDLKGIVFPAGNYSDSYYMAASFTIPDQSDSMLYLAFSEYFFQTSPFAYYITGAFNMTIAEEMSGTQRIGICSYFNINTKIFSSIIPEMLLSNEQSEVPLRTVQRRNRSPEMGEFQIAKCSVAPYLVMLKLMSTEIPVISLQQDSFTVKTQGSVEMFAILPDSTTQSLFTLKIVFLLENILSYILQTEVIPSANAKLSKGFPFPNLANVTLTRPRITIV
    

Molecular Weight27476.43 Da

Isoelectric Point (pI)4.83

Net Charge (pH 7.0)-5.20

Net Charge (pH 7.4) -5.48

Charge Density (pH 7.0) -0.0212

GRAVY Index0.20

Hydrophobic Moment 0.62

Boman Index0.17

Instability Index55.69

Aliphatic Index 95.51

Aromaticity 0.1224

Extinction Coeff. Reduced 16390.00

Extinction Coeff. Oxidized 16515.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0309206 VERIFIED: NO

Provenance & Taxonomy

OrganismChloebia gouldiae [Bacterium]

FamilyBPI

Tax ID44316

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence