Peptide Database

Peptide NamefisB signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC197H311N51O43S2

DescriptionStandard

        MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSL
    

Molecular Weight4146.02 Da

Isoelectric Point (pI)11.84

Net Charge (pH 7.0)5.50

Net Charge (pH 7.4) 5.28

Charge Density (pH 7.0) 0.1571

GRAVY Index0.44

Hydrophobic Moment 0.48

Boman Index0.12

Instability Index37.45

Aliphatic Index 100.00

Aromaticity 0.1714

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1494.69

LogP -7.37

H-bond Donors 55.0

H-bond Acceptors 51.0

Rotatable Bonds 128.0

Heavy Atoms 293.0

Ring Count 10.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058921 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Cutinase secretion

TargetBacillus subtilis TEB1030

MethodSecretion phenotype assay

PaperBrockmeier U, Caspers M, Freudl R, et al. Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria[J]. Journal of Molecular Biology, 2006, 362(3): 393-402. PMID16930615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16930615/