Peptide Database

Peptide NameDermaseptin-SP2 (DRS-SP2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC379H609N99O126S3

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDEEQSEEKRASWKVFLKNIGKAAGKAVLNSVTDMVNQGEQ
    

Molecular Weight8664.67 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-7.47

Net Charge (pH 7.4) -7.74

Charge Density (pH 7.0) -0.0984

GRAVY Index-0.54

Hydrophobic Moment 0.68

Boman Index-0.09

Instability Index66.42

Aliphatic Index 85.92

Aromaticity 0.0658

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3714.00

LogP -35.05

H-bond Donors 125.0

H-bond Acceptors 122.0

Rotatable Bonds 311.0

Heavy Atoms 607.0

Ring Count 6.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149843 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0191427 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0193585 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0196379 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetK. pneumoniae (Gram-negative)

RECORD: Rec_0341103 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus (Gram-positive)