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MYP_126509
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Basic Information
TP4-3
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
25 amino acids
C135H239N43O27
Standard
Sequence
FIIHKKSGGLFKKKAGARKKKRIKK
Physicochemical Analysis
2896.61 Da
12.00
11.84
11.57
0.4735
-1.07
0.52
-0.42
29.18
70.40
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1194.63
-8.59
44.0
40.0
112.0
205.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0093210 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 4, 8, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine.Ⓧ (4) and Ⓧ (8), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
>25 μM
MBC
PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/
RECORD: Rec_0187396 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 4, 8, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine.Ⓧ (4) and Ⓧ (8), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Hemolytic
human red blood cells
100 μM
Hemolysis
PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/
RECORD: Rec_0257703 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 4, 8, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine.Ⓧ (4) and Ⓧ (8), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Cytotoxicity
RAW 264.7 macrophage cells
12.5 μM
Cell death
PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/
RECORD: Rec_0280881 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 4, 8, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine.Ⓧ (4) and Ⓧ (8), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii
3.13 μM
MIC
PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/
RECORD: Rec_0321617 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 4, 8, 18 and 22) in sequence indicates Fmoc-(R)-2-(4-pentenyl) alanine.Ⓧ (4) and Ⓧ (8), Ⓧ (18) and Ⓧ (22) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Cytotoxicity
HaCaT cells
3.13 μM
Cell death
PaperYeh JC, Hazam PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiol Spectr. 2023 Mar 6;11(2):e0385322. PMID36877022 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36877022/
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