Peptide Database

Peptide NameSLAY-screened peptide P4301

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H181N33O31

DescriptionStandard

        PKNTARYDRTSYKVYITRLK
    

Molecular Weight2473.83 Da

Isoelectric Point (pI)10.29

Net Charge (pH 7.0)4.95

Net Charge (pH 7.4) 4.89

Charge Density (pH 7.0) 0.2477

GRAVY Index-1.31

Hydrophobic Moment 0.52

Boman Index-0.45

Instability Index-2.71

Aliphatic Index 58.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1087.99

LogP -10.69

H-bond Donors 42.0

H-bond Acceptors 36.0

Rotatable Bonds 82.0

Heavy Atoms 175.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0214402 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/