Peptide Database

Peptide Nameβ-scorpion toxin Css IV

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Venom / Toxin ▸ General toxin ▸ Toxin-related activity

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC338H490N88O98S8

DescriptionStandard

        KEGYLVNSYTGCKFECFKLGDNDYCLRECRQQYGKGSGGYCYAFGCWCTHLYEQAVVWPLPNKTCN
    

Molecular Weight7610.56 Da

Isoelectric Point (pI)7.68

Net Charge (pH 7.0)0.77

Net Charge (pH 7.4) 0.37

Charge Density (pH 7.0) 0.0117

GRAVY Index-0.52

Hydrophobic Moment 0.48

Boman Index-0.01

Instability Index43.39

Aliphatic Index 45.76

Aromaticity 0.1818

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3019.59

LogP -28.56

H-bond Donors 112.0

H-bond Acceptors 108.0

Rotatable Bonds 242.0

Heavy Atoms 532.0

Ring Count 17.0

Amide Bonds 72.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0031678 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsC-terminal asparagine residue is predicted to undergo amidation; predicted disulphide bond formation between cysteine residues at positions 12 and 65, 16 and 41, 25 and 46, and 29 and 48

Bio-Activity Profile

Function

Receptor agonist Ion channel modulation Toxin-related activity Signaling peptide

TargetNav1.2 (Rat)