Peptide Database

Peptide NameTat-PKI

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC150H258N62O40

DescriptionStandard

        GRKKRRQRRRPPQTYADFIASGRTGRRNAI
    

Molecular Weight3570.04 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)9.76

Net Charge (pH 7.4) 9.55

Charge Density (pH 7.0) 0.3253

GRAVY Index-1.77

Hydrophobic Moment 0.62

Boman Index-0.72

Instability Index126.42

Aliphatic Index 36.00

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1746.27

LogP -23.03

H-bond Donors 66.0

H-bond Acceptors 50.0

Rotatable Bonds 122.0

Heavy Atoms 252.0

Ring Count 4.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0383571 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman immunodeficiency virus 1 [Virus]

FamilyTat

Tax ID11676

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermFluorophore labeling

C-TermNone

Other ModsN-term detail: Rhodamine-labelled

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetCHO K1; HeLa; A549 cells

MethodFluorescence-based uptake assay

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