Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2472H3845N605O724S20

DescriptionStandard

        MAQEQGPQRKGEMMKVWCFILLLSWFTLQLDANPGLKVRITQKGLDFGKEIGMEILKERIKEESFPDWNDSEKFGLSEINYLLSGIRIDTIEFRNTAISLIPGTGIKLTIENAYVIIKANWNIRSWMFKGSGRTTVVISGLSITAMLVMSMDSTGHPSISLDSCQMIASGVEVKLHGKNSWFYNMFTKFLKKSIHRILDSNSCPNLRQEIEIIDMELRILQILMQIDDFAQIDYSLVKSPAVFQSYIDLDLQGTTYPVGNYPAHPYVPVPFALQDSSDSMLYLAVSEYSFQTTVFAYYTTGAFNIIITDEVCSYFNITTETFGSIIPEVAQYYAESQPVMLNLTATKTPVISLQTDAFTIEIHGSMEVLAVLPDATTQSLFTVNITTNSSINLTLFDQKLIGSLCLNRFQLSLADSNLGFFEISLLENFFSYILHSEIIPSANAKLTKGFPLPNLANISLKKPFIKVEQGYLWISADVNYEQ
    

Molecular Weight54264.89 Da

Isoelectric Point (pI)4.98

Net Charge (pH 7.0)-13.97

Net Charge (pH 7.4) -14.68

Charge Density (pH 7.0) -0.0290

GRAVY Index0.10

Hydrophobic Moment 0.74

Boman Index0.16

Instability Index46.89

Aliphatic Index 100.54

Aromaticity 0.1100

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0121074 VERIFIED: YES

Provenance & Taxonomy

OrganismAlligator mississippiensis [Animal]

FamilyBPI/LBP

Tax ID8496

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria